[18F]-DPA-714 PET/CT (Positron Emission Tomography/Computerized Tomography) in Triple Negative Breast Cancers

• Status: Completed
• Trial end date: 2021-07-21
• Target enrollment: 0
• Participant gender: Female

Summary

This phase II study is assessing the correlation between M1/M2 macrophage polarization determined by tumor immunohistochemistry analysis and [18F]DPA-714 PET/CT binding (qualitative and texture analysis) in patients with operable triple negative breast cancer.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Institut Cancerologie de l'Ouest
• Collaborators: SIRIC ILIAD; SIRIC ILIAD : regional consortium led by the health cooperation consortium

Criteria

Inclusion Criteria:

• 18 Years and older

• Triple negative primary breast cancer based on immunohistochemical results as follows:

• Estrogen receptor < 10%

• And Progesterone receptors < 10%

• And HER2 (Human Epidermal Growth Factor Receptor-2) not amplified or not overexpressed

• Patient with a primary tumor eligible for primary surgery

• Performance Status equal to 0 or 1

• Fertile patients must use effective contraception

• Patient must be affiliated to a Social Health Insurance

• Written informed consent

Exclusion Criteria:

• Patient with No triple negative breast cancer

• Patient with inflammatory breast cancer

• Patient with metastatic breast cancer

• Patient receiving cancer treatments such as chemotherapy, immunotherapy, biologic response modifiers, hormonal therapy, and radiotherapy BEFORE the biopsy and PET scans are performed

• Treated diabetes with fasting blood glucose > 10 mmol/L

• Patient who received antibiotics and/or steroidal and/or non-steroidal anti-inflammatory drugs within 30 days PRIOR to [18F]-DPA-714 PET scan

• Contraindication to MRI (implants or metallic prosthesis, severe claustrophobia, pacemaker ...)

• Patient deprived of liberty, under a measure of safeguard of justice, under guardianship or under the authority of a guardian

• Pregnant or nursing patient

• Agitation; impossibility of lying motionless for at least 1 hour, or known claustrophobia